Helper T cell diff erentiation enters a new era
نویسندگان
چکیده
JEM © The Rockefeller University Press $8.00 Vol. 203, No. 4, April 17, 2006 809–812 www.jem.org/cgi/doi/10.1084/jem.20060522 809 In the dark ages of T cell biology, we considered two fates for differentiated CD4+ T cells: T helper (Th)1 and Th2 cells. Now we know that the reality is much more complex and interesting. The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17–related cytokine IL-25 is essential for Th2 responses in two infectious disease models. Helper T cell diff erentiation enters a new era: Le Roi est mort; vive le Roi!
منابع مشابه
Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!
In the dark ages of T cell biology, we considered two fates for differentiated CD4+ T cells: T helper (Th)1 and Th2 cells. Now we know that the reality is much more complex and interesting. The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17-related cytokine IL-25 is essential for Th2 responses in two infectious disease models.
متن کامل5 Francisco Nualart N45-3.indd
Stem cells are considered a valuable cellular resource for tissue replacement therapies in most brain disorders. Stem cells have the ability to self-replicate and diff erentiate into numerous cell types, including neurons, oligodendrocytes and astrocytes. As a result, stem cells have been considered the “holy grail” of modern medical neuroscience. Despite their tremendous therapeutic potential,...
متن کاملTh17 cell function and Th17-mediated autoimmune disease
© 2008 Pappu et al. The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 5 1049-1062 www.jem.org/cgi/doi/ 1049 10.1084/jem.20071364 After activation, CD4 + Th cells diff erentiate into distinct eff ector subsets that are characterized by their unique cytokine expression and immunoregulatory function ( 1, 2 ). A novel Th subset — termed Th IL-17 , Th17, or infl ammatory Th — has bee...
متن کامل12 Manuel Santos N45-3.indd
The new discoveries, the extraordinary dynamism in human stem cell (SC) research, and the great expectations of the benefi ts in clinical treatment of many diseases are on the edge of unparalleled advances in both: 1) the understanding of basic mechanisms of cell diff erentiation and development and 2) the translation from basic research to new clinical therapies. Human stem cells are obtained ...
متن کاملMINK1: The missing link between ROS and its inhibition of Th17 cells
Naive CD4 T helper cells can diff erentiate into distinct lineages depending on the cytokine signals received during T cell activation. Upon TCR and costimulatory molecules signaling during Th17 cell diff erentiation, BATF and IRF4 transcription factors cooperate and function as pioneer transcription factors promoting chromatin remodeling and nucleosome repositioning, allowing the binding of li...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2006